Neurobiology of Disease PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and A
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چکیده
Dany Arsenault,1,2* Alexandre Dal-Pan,2* Cyntia Tremblay,2 David A. Bennett,3 Matthieu J. Guitton,4,5 Yves De Koninck,4,5 Susumu Tonegawa,6 and Frédéric Calon1,2 1Faculté de pharmacie, Université Laval, Quebec City, G1V 0A6, Quebec, Canada, 2Centre Hospitalier de l’Université Laval, Research Center, Quebec City, Quebec, G1V 2L9, Canada, 3Rush Alzheimer’s Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, 4Faculté de médecine, Université Laval, Quebec City, Quebec, G1V 0A6, Canada, 5Institut Universitaire en Santé Mentale de Québec, Quebec City, Quebec, G1J 2G3, Canada, and 6Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
منابع مشابه
PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.
Defects in p21-activated kinase (PAK) are suspected to play a role in cognitive symptoms of Alzheimer's disease (AD). Dysfunction in PAK leads to cofilin activation, drebrin displacement from its actin-binding site, actin depolymerization/severing, and, ultimately, defects in spine dynamics and cognitive impairment in mice. To determine the role of PAK in AD, we first quantified PAK by immunobl...
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Transgenic mouse models of Alzheimer’s disease (AD), such as the 3xTg-AD mice, are instrumental for elucidating genetic, pharmacologic, environmental, and behavioral factors that affect the cognitive phenotype. Here we present the novel findings that longitudinal water-maze spatial training produces a significant, albeit transient, improvement in subsequent learning performance and reduces amyl...
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تاریخ انتشار 2013